What drugs interact with CBD oil

CBD and THC in combination with drugs and other substances

Today, many patients with health problems turn to cannabis products because the medication prescribed by their doctor is insufficient to provide relief or cause side effects.

According to previous studies, there should not have been any strong undesirable side effects, since the patients usually tolerate CBD well. However, it is known that CBD and THC can interfere with the effects of some drugs such as B. could influence antidepressants, be it aggravating or weakening. Therefore, it would by no means be out of place to learn a little more about the possible interactions of CBD and THC with other drugs.

If you want to learn more about possible side effects of CBD oil, just click on the link.

The reasons for the interactions of products made from cannabis with drugs and other substances are known in most cases. Often the point is that the substances or drugs such. B. Antidepressants should have similar mechanisms of action.

In addition, they could mutually influence their effects through similar breakdown pathways (both cannabis and most drugs are broken down in the liver).

Influence each other

THC and CBD could increase or decrease the effects of drugs. However, it can also be the other way around, and some possible effects of CBD and THC could be increased or weakened by the use of certain medications. In both cases there is the possibility of an interaction, i.e. that certain effects increase while others are reduced.

The main interactions with the following drugs:

Antidepressants (selective serotonin reuptake inhibitors): THC could increase the effects of fluoxetine.

Antidepressants (tricyclic): The calming, antihypertensive, and heart rate increasing effects of amitriptylin could be enhanced by ingesting THC.

Benzodiazepines (in sedatives such as ValiumĀ®): CBD and THC can affect the way these drugs work.

Beta blockers: They are used to treat high blood pressure and heart problems because they block the effects of certain hormones (adrenaline, noradrenaline) in the body. They reduce the increase in heart rate caused by the THC.

Glaucoma drugs: In glaucoma, also known as glaucoma, nerve cells are damaged, which in the worst case can lead to blindness. The effects of cannabis and drugs that lower intraocular pressure could occur at the same time and thereby reinforce each other. In rare cases, CBD could cause a slight increase in intraocular pressure.

Medicines that inhibit nausea: There are two main groups of drugs that inhibit nausea and nausea and are often used in cancer patients as part of chemotherapy, namely phenothiazines and serotonin antagonists or "triptans". The effects of such drugs could be increased by THC, as phenothiazines reduce the psychotropic effects of THC.

opiate: The sedative effects and pain relief attributed to both cannabis and opiates could be mutually reinforcing. In addition, CBD is said to counteract the nausea that opiates cause.

THC-containing products in not recommended combinations:

alcohol: When THC and alcohol are consumed at the same time, some effects are increased, such as: B. the calming and sleep-inducing effect, which can affect road safety, as certain essential skills can be impaired.

Substances that increase the heart rate: The effects of THC and the heart rate increasing effects of substances such as B. Amphetamines, adrenaline, atropine and cocaine, when complementary, can prove to be uncomfortable.

Useful advice on how to use cannabis with other medications

If you would like to take cannabis products for possible pain relief in addition to your previous opiate therapy, it is advisable to introduce the use of cannabis extremely slowly and carefully and not to change the medication you are used to under any circumstances.

Different patients react differently and therefore one can never know exactly how certain substances will work, i. That is, whether or not products with cannabis help. If you notice that the symptoms improve with the simultaneous use of cannabis products, you could possibly - in consultation with the treating doctor - try to slowly reduce the dose of the opiates.

In some patients the opiates could be completely discontinued within a period of a few months, whereas in others only a weak effect was noticeable.

It is similar with drugs that are used to relax muscles, e.g. B. in multiple sclerosis or paraplegia. Here, too, the therapy could be supplemented with cannabis products after consultation with the doctor.

Changes in the circulatory system from cannabis use can manifest themselves in two ways, either as a racing pulse or as a feeling of dizziness.

If you want to use cannabis products in addition to drugs that can have an effect on the circulatory system, you should note that this should be done carefully and slowly so as not to put too much strain on the circulatory system.


Numerous studies have indicated that CBD could have a positive effect on many drugs, including antidepressants, which is why adding natural products containing CBD could be useful in the following cases, after consulting your doctor:

  • for pain relief
  • to inhibit nausea and nausea
  • for muscle relaxation
Martin Auerswald is a qualified biochemist and molecular biotechnologist (M. Sc., Technical University of Munich). He specializes in the following topics: applied biochemistry, micronutrients, autoimmune diseases and intestinal health. In clinical research at Erlangen University Hospital, he deals with inflammatory bowel diseases and is editor-in-chief of autoimmunportal.de. Martin's mission is to make the world a little healthier. He supports CBDOele.org in explaining difficult biological or medical topics in a simple and understandable way and thereby giving people the opportunity to regain more health and zest for life.