What is the DSC system

Eight reasons to replace your DSC system

Dynamic differential calorimetry (Differential Scanning Calorimetry, DSC) is an indispensable method for the biophysical characterization of protein stability - a crucial quality feature that is characterized throughout the entire process of biopharmaceutical research and development. This allows the long-term stability of proteins and their formulation conditions to be determined and assessed.

In a DSC system, the protein is heated in solution in the DSC cell. This leads to protein unfolding due to thermal denaturation. The heat capacity of the protein (Cp) changes. The peak of a DSC thermogram represents the melting point (Tm) of the protein. For a protein that reversibly denatures, Tm is the temperature at which 50% of the proteins are in their native (folded) conformity and 50% in denatured (unfolded) conformity. Tm is an established indicator of thermal stability - the higher, the more thermally stable.

The new features optimize productivity, results and confidence in the DSC data. These high-quality, reproducible and reliable DSC data are unambiguous, easy to interpret, universally applicable for all proteins and important for approval applications. MicroCal PEAQ-DSC Automated Systems are a decisive extension of the biophysical characterization portfolio in biopharmaceuticals and research laboratories.